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产品信息
PA5-72870
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LRRC8A antibody for a 15 amino acid peptide near the amino terminus of human LRRC8A. The immunogen is within amino acids 60 - 110 of LRRC8A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718724
靶标信息
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ebo; HsLRRC8A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat containing 8 family member A; leucine-rich repeat-containing 8; Leucine-rich repeat-containing protein 8A; Protein ebouriffe; Swelling protein 1; Volume-regulated anion channel subunit LRRC8A
基因别名: AGM5; KIAA1437; LRRC8; LRRC8A; mKIAA1437; SWELL1; UNQ221/PRO247
UniProt ID: (Human) Q8IWT6, (Mouse) Q80WG5, (Rat) Q4V8I7
Entrez Gene ID: (Human) 56262, (Mouse) 241296, (Rat) 311846
