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LRRC8A (extracellular) Antibody (AAC-001-200UL) in IHC (F)
Expression of LRRC8A in mouse cerebellum and olfactory bulb - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-LRRC8A (extracellular) Antibody (#AAC-001), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488. A. LRRC8A staining in mouse cerebellum (green) shows intensely positive cells (arrows) with Bergmann glia morphology and localization. B. Staining in mouse olfacto... View More
产品信息
AAC-001-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DTGPTGIKYDLDRH, corresponding to amino acid residues 91-104 of human LRRC8A, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ebo; HsLRRC8A; leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat containing 8 family member A; leucine-rich repeat-containing 8; Leucine-rich repeat-containing protein 8A; Protein ebouriffe; Swelling protein 1; Volume-regulated anion channel subunit LRRC8A
基因别名: AGM5; KIAA1437; LRRC8; LRRC8A; mKIAA1437; SWELL1; UNQ221/PRO247
UniProt ID: (Human) Q8IWT6, (Mouse) Q80WG5, (Rat) Q4V8I7
Entrez Gene ID: (Human) 56262, (Mouse) 241296, (Rat) 311846
