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LRRTM2 (extracellular) Antibody (ANR-142-200UL) in IHC (F)
Expression of LRRTM2 in mouse parietal cortex. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-LRRTM2 (extracellular) Antibody (#ANR-142), (1:400), followed by goat Anti-rabbit-AlexaFluor-488. A. LRRTM2 immunoreactivity (green) appears in cortical neurons in layer 5 (arrows). B. Pre-incubation of the Antibody with LRRTM2 (extracellular) Blocking Peptide (BLP-NR142), sup... View More
产品信息
ANR-142-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide CDSQGFHSVPNATDK, corresponding to amino acid residues 47-61 of mouse LRRTM2, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine-rich repeat neuronal 2 protein; leucine-rich repeat transmembrane neuronal 2 protein; Leucine-rich repeat transmembrane neuronal protein 2
基因别名: AI851755; BB129880; C630011A14Rik; KIAA0416; LRRN2; LRRTM2; mKIAA0416
UniProt ID: (Human) O43300, (Mouse) Q8BGA3, (Rat) D4A7P2
Entrez Gene ID: (Human) 26045, (Mouse) 107065, (Rat) 685472
