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产品信息
PA5-54380
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2643576
产品详细信息
Immunogen sequence: PFLTVNDNLK VSFLLPTLRK VNGKDASSTY SQVENLNREL TSRVTAHWEK FMATLGPEEE AEKAQADFVK SAVRD
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 77%.
靶标信息
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CENP-33; Centromere protein 33; Leucine-rich repeat and WD repeat-containing protein 1; leucine-rich repeats and WD repeat domain containing 1; ORC-associated protein; Origin recognition complex-associated protein; testicular tissue protein Li 4
基因别名: CENP-33; LRWD1; ORCA
UniProt ID: (Human) Q9UFC0
Entrez Gene ID: (Human) 222229
