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This antibody is predicted to react with bovine and canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activiation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiqutination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: liver X nuclear receptor alpha variant 1; liver X nuclear receptor beta; Liver X Receptor; Liver X receptor alpha; Liver X receptor beta; LX receptor beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 2; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor
基因别名: LXR-a; LXR-b; LXRA; LXRB; NER; NER-I; NR1H2; NR1H3; RIP15; RLD-1; UNR
UniProt ID: (Human) P55055, (Human) Q13133
Entrez Gene ID: (Human) 7376, (Human) 10062