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产品信息
PA5-20903
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide near the carboxy terminus of human LZTR2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153334
产品详细信息
A suggested positive control is mouse kidney tissue lysate.
PA5-20903 can be used with blocking peptide PEP-1017.
靶标信息
LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine zipper transcription regulator 2; protein SEC16 homolog B; Protein transport protein Sec16B; Regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein; RGPR-p117; SEC16 homolog B
基因别名: KIAA1928; LZTR2; PGPR-p117; RGPR; Rgpr-p117; SEC16B; SEC16S
UniProt ID: (Human) Q96JE7, (Mouse) Q91XT4, (Rat) Q75N33
Entrez Gene ID: (Human) 89866, (Mouse) 89867, (Rat) 89868
transport
endoplasmic reticulum organization
peroxisome organization
positive regulation of gene expression
protein transport
vesicle-mediated transport
peroxisome fission
COPII vesicle coating
positive regulation of protein exit from endoplasmic reticulum
protein localization to endoplasmic reticulum
