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Laminin beta-2/gamma-1 Antibody (MA5-47722) in ICC/IF
Immunocytochemistry analysis of Laminin beta-2/gamma-1 in aldehyde fixed and NP-40 permeabilized human MDA-MB-231 breast carcinoma cells. The cells were labeled with mouse Laminin beta-2/gamma-1 monoclonal antibody (Product # MA5-47722). The antibody was detected using goat anti-mouse DyLight® 594.
产品信息
MA5-47722
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
M046
抗原
Clone (M046) was generated from a recombinant human laminin 521 protein that includes a heterotrimer of three subunits laminin alpha5, laminin beta2, and laminin gamma1 subunits.
偶联物
形式
Liquid
浓度
~1.0 mg/mL
纯化类型
Protein G
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2942703
产品详细信息
Clone M046 detects native laminin isoforms that include both laminin beta2 and gamma1 subunits. In native immunoblots, the antibody detects laminin 521, laminin 221, and laminin 121, but does not detect lamin 332 and laminin 411. The antibody weakly detects laminin 511. This antibody can be used for immunocytochemical detection of laminin beta2/gamma1 subunits, and can also be used for detection of native laminin isoforms in immunoblots and ELISA.
靶标信息
Laminins are large heterotrimeric, noncollagenous glycoproteins composed of alpha, beta, and gamma chains. They are ubiquitously present in basement membrane (BM) along with entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AA408497; Lama; Laminin B1s chain; Laminin B2 chain; laminin S; Laminin subunit beta-2; Laminin subunit gamma-1; laminin, beta 2 (laminin S); laminin, gamma 1 (formerly LAMB2); Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit beta; Laminin-11 subunit gamma; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-2 subunit gamma; Laminin-3 subunit beta; Laminin-3 subunit gamma; Laminin-4 subunit beta; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit beta; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit beta; Laminin-9 subunit gamma; S-LAM beta; S-LAM gamma; S-laminin subunit beta; S-laminin subunit gamma
基因别名: LAMB2; LAMC1; LAMS; NPHS5
UniProt ID: (Human) P55268, (Human) P11047
Entrez Gene ID: (Human) 3913, (Human) 3915
cell adhesion
axon guidance
neuromuscular junction development
visual perception
astrocyte development
Schwann cell development
extracellular matrix organization
axon extension involved in regeneration
retina development in camera-type eye
metanephric glomerular visceral epithelial cell development
metanephric glomerular basement membrane development
protein complex assembly
endoderm development
cell migration
extracellular matrix disassembly
hemidesmosome assembly
substrate adhesion-dependent cell spreading
positive regulation of epithelial cell proliferation
