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Lefty1/Lefty2 Antibody (MA5-38044) in IHC (P)
Immunohistochemistry analysis of Lefty1/Lefty2 in paraffin-embedded human colon carcinoma. Samples were incubated with Lefty1/Lefty2 Monoclonal antibody (Product # MA5-38044) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-38044
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2149
抗原
A synthetic peptide corresponding to a sequence within amino acids 267-366 of human LEFTY1/2 (O75610)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897962
产品详细信息
Positive Samples: HT-29, BxPC-3, Mouse brain, Rat brain
Immunogen sequence: EMYIDLQGMK WAENWVLEPP GFLAYECVGT CRQPPEALAF KWPFLGPRQC IASETDSLPM IVSIKEGGRT RPQVVSLPNM RVQKCSCASD GALVPRRLQP
靶标信息
Left-right determination factor 1 and 2 (Lefty1/2) belong to the TGF-beta superfamily of proteins and are responsible for determination of left-right positioning of visceral organs during embryogenesis. Lefty1 acts as a regulator of Lefty2 and NODAL as the lack of the former resulted in bilateral expression of nodal, lefty2 and Pitx2 (a homeobox gene normally expressed on the left side and blocks the signal for leftness). Lefty2 may play a role in endometrial bleeding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left-right determination factor 1; Left-right determination factor 2; Left-right determination factor A; Left-right determination factor B; left-right determination, factor A; left-right determination, factor B; Lefty protein; Protein lefty-1; Protein lefty-2; Protein lefty-A; Protein lefty-B; Stimulated by retinoic acid gene 3 protein; TGF-beta-4; Transforming growth factor beta-4
基因别名: 6030463A22Rik; AI450052; AV214969; EBAF; Ebaf2; LEFTA; LEFTB; Lefty; lefty-1; LEFTY1; LEFTY2; LEFTYA; LEFTYB; PSEC0024; RGD1561867; Stra3; TGFB4; UNQ278/PRO317
UniProt ID: (Human) O75610, (Human) O00292, (Mouse) Q64280, (Mouse) P57785
Entrez Gene ID: (Human) 10637, (Human) 7044, (Rat) 498299, (Mouse) 13590, (Rat) 289316, (Mouse) 320202
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transforming growth factor beta receptor signaling pathway
determination of left/right symmetry
positive regulation of pathway-restricted SMAD protein phosphorylation
cell growth
regulation of apoptotic process
regulation of MAPK cascade
cell development
SMAD protein signal transduction
platelet degranulation
multicellular organism development
negative regulation of cell proliferation
anterior/posterior axis specification
response to retinoic acid
cell migration involved in gastrulation
negative regulation of nodal signaling pathway
negative regulation of nodal receptor complex assembly
growth
biological_process
