NeoBiotechnologies

Leptin Receptor (LEPR)/Ob-R/CD295 Monoclonal Antibody (LEPR/4545)

Leptin Receptor (LEPR)/Ob-R/CD295 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Leptin Receptor (LEPR)/Ob-R/CD295 Antibody (3953-MSM5-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human hepatocellular carcinoma stained with Leptin Receptor Mouse Monoclonal Antibody (LEPR/4545). HIER: Tris/EDTA, pH9.0, 45 min. 2 °: HRP-polymer, 30 min. DAB, 5 min.

Leptin Receptor (LEPR)/Ob-R/CD295 Antibody in Peptide array (ARRAY)

Leptin Receptor (LEPR)/Ob-R/CD295 Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

3953-MSM5-P0

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

肽阵列 (Array)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

LEPR/4545

抗原

Recombinant fragment (around aa335-425) of human LEPR protein.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.

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