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产品信息
M710
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
7N41
抗原
Recombinant human IFN alpha 2b
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_223581
产品详细信息
M710 targets IFN alpha in ELISA applications and shows reactivity with Human samples.
The M710 immunogen is recombinant human IFN alpha 2b.
M710 detects IFN alpha which has a predicted molecular weight of approximately 19 kDa.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).
靶标信息
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha-2a interferon; ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha leukocyte (IFL); Interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); interferon, alpha 1; interferon, alpha 2; interferon-alpha1; LeIF A; LeIF D; MGC138207; MGC138505; MGC138507
基因别名: IFL; IFN; IFN-ALPHA; IFN-alphaA; IFN-alphaD; IFNA; IFNA1; IFNA13; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNA@; INFA2
UniProt ID: (Human) P01562, (Human) P01563
Entrez Gene ID: (Human) 3439, (Human) 3440
T cell activation involved in immune response
natural killer cell activation involved in immune response
apoptotic process
inflammatory response
humoral immune response
cell surface receptor signaling pathway
cell-cell signaling
blood coagulation
negative regulation of gene expression
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
B cell proliferation
positive regulation of phosphorylation
positive regulation of tyrosine phosphorylation of Stat3 protein
response to exogenous dsRNA
innate immune response
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
negative regulation of T-helper 2 cell cytokine production
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
adaptive immune response
