Invitrogen

CD40 Monoclonal Antibody (LOB7/6)

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CD40 Antibody (MA1-80926) in Flow

Flow cytometric analysis of human peripheral blood lymphocytes using a CD40/Bp50 monoclonal antibody (Product # MA1-80926)

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产品信息

MA1-80926

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-10 µg/mL

免疫组化（冰冻） (IHC (F))

1-10 µg/mL

流式细胞分析 (Flow)

20 µg/mL

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Dog, Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

LOB7/6

抗原

CD40 Ig(Fc) fusion protein containing the EC region of human CD40 and Fc region of human IgG

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS

内含物

<0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_928288

产品详细信息

This product requires protein digestion pre-treatment of paraffin sections using trypsin or pronase. A suggested positive control for immunohistochemical applications is human tonsil. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Mouse anti Human CD40 antibody, clone LOB7/6 recognizes the human CD40 cell surface antigen, a 48kDa glycoprotein expressed by B lymphocytes and weakly by some monocytes.

靶标信息

The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; CD40; CD40 antigen (TNF receptor superfamily member 5); CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; Immunoglobulin M; ImmunoglobulinM; MGC9013; sCD40; soluble CD40; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5

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基因别名: Bp50; CD40; CDW40; p50; TNFRSF5

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UniProt ID: (Dog) Q7YRL5, (Human) P25942

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Entrez Gene ID: (Dog) 403469, (Human) 958

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功能

tumor necrosis factor-activated receptor activity antigen binding signal transducer activity receptor activity protein binding enzyme binding ubiquitin protein ligase binding

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