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Phospho-c-Cbl (Tyr700) Antibody (MA5-37106) in Flow
Flow cytometry of Phospho-c-Cbl (Tyr700) using C6 cells. Samples were incubated in monoclonal Phospho-c-Cbl (Tyr700) antibody (Product # MA5-37106). Images correspond with the following conditions: cell only negative control (blue), treated with imatinib (red), with pervanadate (green).
产品信息
MA5-37106
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
CblY700-E1
抗原
A synthetic phospho-peptide corresponding to residues surrounding Tyr700 of human phospho c-Cbl.
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
PBS with 0.20% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897040
靶标信息
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
基因别名: 4732447J05Rik; C-CBL; CBL; Cbl-2; CBL2; FRA11B; NSLL; RGD1561386; RNF55
UniProt ID: (Human) P22681, (Mouse) P22682
Entrez Gene ID: (Human) 867, (Mouse) 12402, (Rat) 500985
phosphotyrosine binding
transcription factor activity, sequence-specific DNA binding
ubiquitin-protein transferase activity
signal transducer activity
calcium ion binding
protein binding
zinc ion binding
ligase activity
SH3 domain binding
protein kinase binding
ephrin receptor binding
ubiquitin protein ligase activity
cadherin binding involved in cell-cell adhesion
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ligase
metabolite interconversion enzyme
regulation of transcription, DNA-templated
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
protein ubiquitination
negative regulation of epidermal growth factor receptor signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of receptor-mediated endocytosis
cell-cell adhesion
regulation of signaling
