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MAFA Antibody (720262) in WB
Western blot analysis was performed on nuclear extracts (30 µg lysate) of MCF-7 (Lane 1), U-2 OS (Lane 2), HEK-293 (Lane 3) and tissue extracts of Rat brain (Lane 4). The blots were probed with Anti-MAFA Rabbit Polyclonal antibody (Product # 720262, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A ~ 48 kDa band corresponding to MAFA was observed. The molecular weight of MAFA has been reported in literature t... View More
产品信息
720262
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptides corresponding to Human MAFA (aa 331-343, 28-41)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633223
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Mouse, Rat and Bovine
靶标信息
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its ocogenic activity. Serves as an ocogene or tumor supressor depending on the cell context.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; Transcription factor MafA; transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
基因别名: hMafA; MAFA; RGD1562627; RIPE3b1
UniProt ID: (Human) Q8NHW3
Entrez Gene ID: (Human) 389692, (Rat) 366949
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
protein heterodimerization activity
protein binding
sequence-specific DNA binding
basic leucine zipper transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nitric oxide mediated signal transduction
response to glucose
insulin secretion
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of transcription, DNA-templated
