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产品信息
MA5-44325
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR067G
抗原
Peptide representing a region between residue 125 and 175 of human MAF bZIP transcription factor A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
BBS, pH 8.2
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Wet ice
RRID
AB_2926455
产品详细信息
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
靶标信息
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its ocogenic activity. Serves as an ocogene or tumor supressor depending on the cell context.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; Transcription factor MafA; transcription factor RIPE3b1; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
基因别名: hMafA; MAFA; RIPE3b1
UniProt ID: (Human) Q8NHW3
Entrez Gene ID: (Human) 389692
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
protein heterodimerization activity
basic leucine zipper transcription factor
