Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
MAGI2 Antibody (PA5-47901) in ICC/IF
Immunocytochemistry analysis of MAGI2 in immersion fixed U‚87 MG human glioblastoma/astrocytoma cell line. Samples were incubated in MAGI2 polyclonal antibody (Product # PA5-47901) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm.
产品信息
PA5-47901
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human MAGI2 Ser2-Arg130
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606999
产品详细信息
In direct ELISAs, less than 1% cross-reactivity with recombinant ARIP-2 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activin receptor interacting protein 1; Activin receptor-interacting protein 1; Acvrip1; AIP-1; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
基因别名: Acvri1; ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; KIAA0705; MAGI-2; MAGI2; mKIAA0705; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Mouse) Q9WVQ1
Entrez Gene ID: (Human) 9863, (Mouse) 50791
positive regulation of receptor internalization
planar cell polarity pathway involved in axis elongation
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of cell migration
positive regulation of phosphoprotein phosphatase activity
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
protein heterooligomerization
negative regulation of protein kinase B signaling
SMAD protein signal transduction
mitotic cell cycle arrest
glomerular visceral epithelial cell development
neuroligin clustering involved in postsynaptic membrane assembly
cellular response to nerve growth factor stimulus
positive regulation of synaptic vesicle clustering
signal transduction
nervous system development
cytosolic transport
