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产品信息
PA5-50029
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from internal of human MAN1B1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2635482
产品详细信息
The antibody detects endogenous levels of total MAN1B1 protein.
靶标信息
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544]. Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699]. Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3.2.1.113; endoplasmic Reticulum Class I alpha-mannosidase; Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; ER alpha 1,2-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Man9GlcNAc2-specific processing alpha-mannosidase; Man9GlcNAc2-specific-processing alpha-mannosidase; Mannosidase alpha class 1B member 1; mannosidase, alpha, class 1B, member 1; RP11-350O14.2
基因别名: E430019H13Rik; ERMAN1; ERManI; Gm108; MAN1B1; MANA-ER; MRT15; UNQ747/PRO1477
UniProt ID: (Human) Q9UKM7, (Mouse) A2AJ15
Entrez Gene ID: (Human) 11253, (Mouse) 227619
alpha-mannosidase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
calcium ion binding
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
protein modifying enzyme
N-glycan processing
oligosaccharide metabolic process
ER-associated ubiquitin-dependent protein catabolic process
protein alpha-1,2-demannosylation
trimming of terminal mannose on B branch
endoplasmic reticulum mannose trimming
mannose trimming involved in glycoprotein ERAD pathway
metabolic process
