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产品信息
H00005595-M03
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1E2
抗原
MAPK3 (AAH13992, 279 a.a. approximately 379 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: NYLQSLPSKT KVAWAKLFPK SDSKALDLLD RMLTFNPNKR ITVEEALAHP YLEQYYDPTD EPVAEEPFTF AMELDDLPKE RLKELIFQET ARFQPGVLEA P
靶标信息
MAPK3 (ERK1) is a serine/threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERK; ERK-1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK2; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 3; p44-ERK1; p44-MAPK
基因别名: ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; MAPK3; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3
UniProt ID: (Human) P27361
Entrez Gene ID: (Human) 5595
MAPK cascade
activation of MAPK activity
MAPK import into nucleus
positive regulation of protein phosphorylation
transcription initiation from RNA polymerase I promoter
protein complex assembly
protein phosphorylation
apoptotic process
DNA damage induced protein phosphorylation
cell cycle
axon guidance
fibroblast growth factor receptor signaling pathway
response to toxic substance
regulation of phosphatidylinositol 3-kinase signaling
viral process
phosphorylation
peptidyl-serine phosphorylation
sensory perception of pain
arachidonic acid metabolic process
platelet activation
BMP signaling pathway
thyroid gland development
positive regulation of cyclase activity
lipopolysaccharide-mediated signaling pathway
positive regulation of telomere maintenance via telomerase
regulation of stress-activated MAPK cascade
positive regulation of histone phosphorylation
positive regulation of histone acetylation
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
outer ear morphogenesis
response to exogenous dsRNA
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
thymus development
regulation of sequence-specific DNA binding transcription factor activity
cartilage development
regulation of cytoskeleton organization
positive regulation of telomerase activity
Bergmann glial cell differentiation
face development
JAK-STAT cascade involved in growth hormone signaling pathway
lung morphogenesis
trachea formation
cardiac neural crest cell development involved in heart development
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
response to epidermal growth factor
cellular response to mechanical stimulus
caveolin-mediated endocytosis
regulation of Golgi inheritance
regulation of cellular response to heat
positive regulation of telomere capping
positive regulation of xenophagy
regulation of early endosome to late endosome transport
negative regulation of apolipoprotein binding
