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产品信息
BMS170
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
CA102.2C1
抗原
Rec. Human MadCAM-1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10596496
产品详细信息
Description: This antigen is expressed in mucosal lymphoid tissue and lamina propria and is a counter-receptor for CD62L and CD49d. MAdCAM-1 is involved in homing of subpopulation of memory T cells to the gut lamina propria, and recirculation of naive lymphocytes in Peyer's patches and mesenteric lymph nodes.
The 1F3F3D4 antibody reacts with mouse tumor necrosis factor-alpha (TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4(+) T cells.
Applications Tested: ELISA, Functional Studies (Blocking), Western Blotting.
靶标信息
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hMAdCAM-1; MAdCAM-1; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1
基因别名: MACAM1; MADCAM1
UniProt ID: (Human) Q13477
Entrez Gene ID: (Human) 8174
positive regulation of leukocyte migration
immune response
cell adhesion
cell-matrix adhesion
signal transduction
integrin-mediated signaling pathway
aging
extracellular matrix organization
heterotypic cell-cell adhesion
receptor clustering
regulation of immune response
leukocyte tethering or rolling
