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产品信息
PA5-28277
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 123 and 349 of Human MBD2
偶联物
形式
Liquid
浓度
0.48 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545753
产品详细信息
Recommended positive controls: A431, Jurkat, Raji.
Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (89%), Chicken (82%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Demethylase; DKFZp586O0821; DMTase; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2
基因别名: DMTase; MBD2; NY-CO-41
UniProt ID: (Human) Q9UBB5
Entrez Gene ID: (Human) 8932
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
satellite DNA binding
mRNA binding
protein binding
methyl-CpG binding
protein domain specific binding
nucleosomal DNA binding
siRNA binding
C2H2 zinc finger domain binding
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
methylation-dependent chromatin silencing
transcription, DNA-templated
positive regulation of Wnt signaling pathway
regulation of cell proliferation
maternal behavior
ATP-dependent chromatin remodeling
cellular protein complex assembly
negative regulation of transcription, DNA-templated
