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MC1 Receptor Antibody (AMR-020-200UL) in ICC/IF
Expression of MC1R in human Malme-3M cells - Immunocytochemical staining of human paraformaldehyde fixed and permeabilized malignant melanoma cell lines (Malme-3M). A. Cells were stained with Anti-MC1 Receptor Antibody (#AMR-020), (1:200) followed by goat- Anti-rabbit-AlexaFluor-555 secondary Antibody . B. Live view of the same field as in (A).C. Computer merge of (A) and (B).
产品信息
AMR-020-200UL
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HAQGIARLHKRQRPVH, corresponding to amino acid residues 217-232 of human MC1R, 3rd intracellular loop
偶联物
形式
Lyophilized
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha melanocyte stimulating hormone receptor; MC1 receptor; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R
基因别名: CMM5; MC1R; MSH-R; MSHR; SHEP2
UniProt ID: (Human) Q9UN59
Entrez Gene ID: (Human) 4157, (Rat) 102552838
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
multicellular organism development
UV protection
positive regulation of protein kinase A signaling
sensory perception of pain
positive regulation of cAMP biosynthetic process
negative regulation of tumor necrosis factor production
intracellular signal transduction
melanin biosynthetic process
pigmentation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
UV-damage excision repair
positive regulation of protein kinase C signaling
G-protein coupled receptor signaling pathway
regulation of feeding behavior
positive regulation of feeding behavior
