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产品信息
PA1-23524
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, conjugated to KLH, corresponding to the 3rd cytoplasmic domain of human Melanocortin 1 Receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_560021
产品详细信息
PA1-23524 detects melanocortin 1 receptor in human samples.
靶标信息
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
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生物信息学
蛋白别名: alpha melanocyte stimulating hormone receptor; MC1 receptor; MC1-R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R
基因别名: CMM5; MC1R; MSH-R; MSHR; SHEP2
UniProt ID: (Human) Q01726
Entrez Gene ID: (Human) 4157
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
multicellular organism development
UV protection
positive regulation of protein kinase A signaling
sensory perception of pain
positive regulation of cAMP biosynthetic process
negative regulation of tumor necrosis factor production
intracellular signal transduction
melanin biosynthetic process
pigmentation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
UV-damage excision repair
positive regulation of protein kinase C signaling
