Invitrogen

MC1R Polyclonal Antibody

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MC1R Antibody (PA5-75342) in WB

Western blot analysis of MC1R in various lysates. Samples were incubated with MC1R polyclonal antibody (Product # PA5-75342) using a dilution of 1:1,000. Lane 1: Hela whole cell lysate (40 µg); Lane 2: The Brain tissue lysate of Rat (40 µg); Lane 3: The Brain tissue lysate of Mouse (40 µg).

MC1R Antibody in Immunohistochemistry (Frozen) (IHC (F))

MC1R Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-75342

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化 (IHC)

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免疫组织化学（多聚甲醛固定） (IHC (PFA))

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免疫组化（冰冻） (IHC (F))

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免疫细胞化学 (ICC/IF)

1:50-1:200

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 271-317 of Human MC1-R.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2719070

产品详细信息

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

靶标信息

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model.

Oxidative medicine and cellular longevity

Yu S,Doycheva DM,Gamdzyk M,Gao Y,Guo Y,Travis ZD,Tang J,Chen WX,Zhang JH

PA5-75342 was used in Western Blot, Immunohistochemistry to study the role of melanocortin-1 receptor (MC1R) activation with BMS-470539 in attenuating oxidative stress and neuronal apoptosis induced by hypoxic ischemia and the underlying mechanisms.

Fri Mar 18 00:00:00 UTC 2022

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model.

Oxidative medicine and cellular longevity

Yu S,Doycheva DM,Gamdzyk M,Gao Y,Guo Y,Travis ZD,Tang J,Chen WX,Zhang JH

Fri Mar 18 00:00:00 UTC 2022

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model.

Oxidative medicine and cellular longevity

Yu S,Doycheva DM,Gamdzyk M,Gao Y,Guo Y,Travis ZD,Tang J,Chen WX,Zhang JH

Fri Mar 18 00:00:00 UTC 2022

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model.

Oxidative medicine and cellular longevity

Yu S,Doycheva DM,Gamdzyk M,Gao Y,Guo Y,Travis ZD,Tang J,Chen WX,Zhang JH

Fri Mar 18 00:00:00 UTC 2022

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats.

Journal of neuroinflammation

Yu S,Doycheva DM,Gamdzyk M,Yang Y,Lenahan C,Li G,Li D,Lian L,Tang J,Lu J,Zhang JH

PA5-75342 was used in Western Blot, Immunocytochemistry to explore the role of MC1R activation on neuroinflammation and the potential underlying mechanisms after neonatal hypoxic-ischemic brain injury in rats.

Tue Jan 19 00:00:00 UTC 2021

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats.

Journal of neuroinflammation

Yu S,Doycheva DM,Gamdzyk M,Yang Y,Lenahan C,Li G,Li D,Lian L,Tang J,Lu J,Zhang JH

Tue Jan 19 00:00:00 UTC 2021

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats.

Journal of neuroinflammation

Yu S,Doycheva DM,Gamdzyk M,Yang Y,Lenahan C,Li G,Li D,Lian L,Tang J,Lu J,Zhang JH

Tue Jan 19 00:00:00 UTC 2021

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats.

Journal of neuroinflammation

Yu S,Doycheva DM,Gamdzyk M,Yang Y,Lenahan C,Li G,Li D,Lian L,Tang J,Lu J,Zhang JH

Tue Jan 19 00:00:00 UTC 2021

Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats.

Theranostics

Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

PA5-75342 was used in Immunohistochemistry, Western Blot to study the neuroprotective mechanisms of the BMS-470539/MC1R system which attunates early brain injury following subarachnoid hemorrhage by suppressing the oxidative stress, apoptosis, and mitochondrial fission through the AMPK/SIRT1/PGC-1α signaling pathway.

Wed Aug 04 00:00:00 UTC 2021

Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats.

Theranostics

Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

Wed Aug 04 00:00:00 UTC 2021

Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats.

Theranostics

Xu W,Yan J,Ocak U,Lenahan C,Shao A,Tang J,Zhang J,Zhang JH

Wed Aug 04 00:00:00 UTC 2021

Visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system against immune-associated nephropathy without glucocorticoid side effect.

Theranostics

Fan K,Zeng L,Guo J,Xie S,Yu Y,Chen J,Cao J,Xiang Q,Zhang S,Luo Y,Deng Q,Zhou Q,Zhao Y,Hao L,Wang Z,Zhong L

PA5-75342 was used in Immunohistochemistry to provide a promising strategy of Dex/PFP@LIPs-BMS-α as effective and safe against immune-associated nephropathy.

Tue Jul 27 00:00:00 UTC 2021

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Xu W,Mo J,Ocak U,Travis ZD,Enkhjargal B,Zhang T,Wu P,Peng J,Li T,Zuo Y,Shao A,Tang J,Zhang J,Zhang JH

PA5-75342 was used in Immunohistochemistry (PFA fixed) to study the hypothesis that activation of melanocortin 1 receptor (MC1R) with BMS-470539 attenuates EBI by suppression of neuroinflammation after SAH.

Wed Jan 01 00:00:00 UTC 2020

生物信息学

蛋白别名: alpha melanocyte stimulating hormone receptor; extension recessive yellow; MC1 receptor; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; melanocortin-1 receptor; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; tobacco darkening

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基因别名: CMM5; e; MC1R; MSH-R; MSHR; Mshra; SHEP2; Tob

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UniProt ID: (Human) Q9UN59, (Mouse) Q01727

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Entrez Gene ID: (Human) 4157, (Rat) 102552838, (Mouse) 17199

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功能

melanocortin receptor activity melanocyte-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity ubiquitin protein ligase binding hormone binding signal transducer activity G-protein coupled receptor activity G-protein coupled receptor

参与通路