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产品信息
PA5-20759
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide near the amino terminus of human MC4R.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152201
产品详细信息
A suggested positive control is rat brain tissue lysate.
PA5-20759 can be used with blocking peptide PEP-0873.
靶标信息
Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MC4; MC4 receptor; MC4-R; Melanocortin receptor 4
基因别名: Mc4-r; MC4R
UniProt ID: (Human) P32245, (Rat) P70596, (Mouse) P56450
Entrez Gene ID: (Human) 4160, (Rat) 25635, (Mouse) 17202
diet induced thermogenesis
energy reserve metabolic process
G-protein coupled receptor signaling pathway
feeding behavior
regulation of metabolic process
insulin secretion
positive regulation of cAMP biosynthetic process
response to insulin
positive regulation of bone resorption
regulation of feeding behavior
negative regulation of feeding behavior
regulation of grooming behavior
signal transduction
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
