Invitrogen

MC4R Polyclonal Antibody

MC4R Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MC4R Antibody (PA5-33926) in IHC (P)

Immunohistochemistry analysis of MC4R in human brain neurons and glia. Samples were incubated with MC4R polyclonal antibody (Product # PA5-33926). Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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产品信息

PA5-33926

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

2.5-5 µg/mL

产品规格

种属反应

Human, Non-human primate, Sheep, Rabbit

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC4 Receptor.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.1% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2551294

产品详细信息

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Tamarin, Sheep, Rabbit (100%).

靶标信息

Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

仅用于科研。不用于诊断过程。未经明确授权不得转售。