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MCM10 Antibody (PA5-100043) in IHC (P)
Immunohistochemistry analysis of MCM10 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MCM10 polyclonal antibody (Product # PA5-100043) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-100043
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MCM10(Accession Q7L590), corresponding to amino acid residues S822-N872.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815573
产品详细信息
Antibody detects endogenous levels of total MCM10.
靶标信息
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of yeast MCM10; HsMCM10; MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance complex component 10; minichromosome maintenance deficient 10; Protein MCM10 homolog
基因别名: 2410041F14Rik; AU018508; C330019M07Rik; C79164; CNA43; DNA43; MCM10; PRO2249
UniProt ID: (Human) Q7L590, (Mouse) Q0VBD2
Entrez Gene ID: (Human) 55388, (Rat) 307126, (Mouse) 70024
