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Product Details
MA5-34701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JB99-35
Immunogen
Synthetic peptide within Human MCM3 aa 1-50
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
RRID
AB_2848609
Product Specific Information
Positive Control: Mouse thymus tissue lysate, NIH-3T3, Hela, 293T, HepG2, SH-SY-5Y, rat testis tissue, human tonsil tissue, human placenta tissue, mouse small intestine tissue, K562.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cervical cancer proto-oncogene 5; DNA polymerase alpha holoenzyme-associated protein P1; DNA replication factor MCM3; DNA replication licensing factor MCM3; hRlf beta subunit; MCM3 minichromosome maintenance deficient 3; MGC1157; minichromosome maintenance deficient 3; P1-MCM3; p102; replication licensing factor, beta subunit; RLF subunit beta; RP1-108C2.3
Gene Aliases: HCC5; MCM3; P1-MCM3; P1.h; RLFB
UniProt ID: (Human) P25205
Entrez Gene ID: (Human) 4172
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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