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MCP-5 Antibody (MA5-23841) in Neu
Neutralization of MCP-5 in BaF3 mouse pro‚B cell line transfected with human CCR2A. Samples were incubated in MCP-5 monoclonal antibody (Product # MA5-23841). Recombinant Mouse CCL12/MCP‚5 chemoattracts the BaF3 mouse pro‚B cell line transfected with human CCR2A in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse CCL12/MCP‚5 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse ... View More
产品信息
MA5-23841
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
63205
抗原
E. coli-derived recombinant mouse CCL12/MCP-5 Gly23-Gly104
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2607350
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C motif chemokine 12; MCP-1-related chemokine; MCP-5; Monocyte chemoattractant protein 5; Monocyte chemotactic protein 5; small inducible cytokine A12; Small-inducible cytokine A12
基因别名: Ccl12; MCP-5; Mcp5; Scya12
UniProt ID: (Mouse) Q62401
Entrez Gene ID: (Mouse) 20293
MAPK cascade
angiogenesis
monocyte chemotaxis
positive regulation of leukocyte migration
chemotaxis
inflammatory response
immune response
cytoskeleton organization
regulation of cell shape
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
negative regulation of glial cell apoptotic process
protein kinase B signaling
negative regulation of neuron apoptotic process
astrocyte cell migration
macrophage chemotaxis
negative regulation of leukocyte proliferation
cellular response to organic cyclic compound
positive regulation of calcium ion import
negative regulation of natural killer cell chemotaxis
