Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 17
MCRS1 Antibody (PA5-103072) in IHC (P)
Immunohistochemistry analysis of MCRS1 in mouse colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MCRS1 polyclonal antibody (Product # PA5-103072) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-103072
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MCRS1(Accession Q96EZ8), corresponding to amino acid residues M1-S48.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852442
产品详细信息
Antibody detects endogenous levels of total MCRS1.
靶标信息
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1; nucleolar protein
基因别名: C78274; ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78
UniProt ID: (Human) Q96EZ8, (Mouse) Q99L90
Entrez Gene ID: (Human) 10445, (Rat) 300222, (Mouse) 51812
biological_process
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
DNA repair
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
cellular protein modification process
positive regulation of protein localization to nucleolus
