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产品信息
PA5-142482
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-SKSTTSQIPLQAQED (aa 148-162).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933130
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
靶标信息
MDFI is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. MDFI an also interfere with the DNA-binding activity of Myod family members and plays an important role in trophoblast and chondrogenic differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: inhibitor of MyoD family a; MyoD family inhibitor; Myogenic repressor I-mf
基因别名: I-MF; I-mfa; MDFI
UniProt ID: (Human) Q99750
Entrez Gene ID: (Human) 4188
negative regulation of transcription from RNA polymerase II promoter
activation of JUN kinase activity
embryo development
dorsal/ventral axis specification
negative regulation of Wnt signaling pathway
cytoplasmic sequestering of transcription factor
negative regulation of DNA binding
negative regulation of transcription, DNA-templated
embryonic skeletal system morphogenesis
trophoblast giant cell differentiation
