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ME2 Antibody (PA5-78057) in IHC (P)
ME2 Polyclonal Antibody detects ME2 protein at cytoplasm in mouse muscle by immunohistochemical analysis. Sample: Paraffin-embedded mouse muscle. ME2 Polyclonal Antibody (Product # PA5-78057) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-78057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human ME2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2736131
Product Specific Information
Positive Control: THP-1, HL-60
Predicted Reactivity: Rat (87%), Bovine (91%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ME2 encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; NAD-dependent malic enzyme, mitochondrial; NAD-ME; pyruvic-malic carboxylase
Gene Aliases: AW120568; D030040L20Rik; ME2; NAD-ME; ODS1
UniProt ID: (Human) P23368, (Mouse) Q99KE1
Entrez Gene ID: (Human) 4200, (Mouse) 107029
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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