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产品信息
IHC-00180
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residues 2150 and the C-terminus (residue 2212) of human Mediator of RNA Polymerase II Transcription, subunit 12.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Pig, Panda, Orangutan, Monkey, Chimpanzee, Naked mole rat and Small-eared galago
靶标信息
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C.
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生物信息学
蛋白别名: Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; human opposite paired; Mediator complex subunit 12; Mediator of RNA polymerase II transcription subunit 12; mediator of RNA polymerase II transcription, subunit 12 homolog; OPA-containing protein; OPA-containing protein 1; putative mediator subunit 12; Thyroid hormone receptor-associated protein complex 230 kDa component; thyroid hormone receptor-associated protein, 230 kDa subunit; Trap230; trinucleotide repeat containing 11 (THR-associated protein); trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); Trinucleotide repeat-containing gene 11 protein
基因别名: 230kDa; ARC240; CAGH45; FGS1; HOPA; KIAA0192; MED12; MED12S; Mopa; OHDOX; OKS; OPA-1; OPA1; TNRC11; TRAP230
UniProt ID: (Human) Q93074, (Mouse) A2AGH6
Entrez Gene ID: (Human) 9968, (Mouse) 59024
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription cofactor activity
RNA polymerase II transcription coactivator activity
chromatin binding
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
beta-catenin binding
protein C-terminus binding
protein domain specific binding
ligand-dependent nuclear receptor transcription coactivator activity
vitamin D receptor binding
thyroid hormone receptor binding
ubiquitin protein ligase activity
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription factor binding
general transcription factor
neural tube closure
transcription initiation from RNA polymerase II promoter
endoderm development
heart development
oligodendrocyte development
Schwann cell development
protein ubiquitination
stem cell population maintenance
spinal cord development
negative regulation of Wnt signaling pathway
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
post-anal tail morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic neurocranium morphogenesis
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
axis elongation involved in somitogenesis
embryonic brain development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
