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Immunogen sequence: LSVTASTRPR SPVGENADEH YSKDHDVKME IFSPMPGESC ENANTSLGRR MSVNCEKLVK REKPRELIFP SNYDLL
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 84%.
MED12L, also named as KIAA1635, TNRC11L, TRALP and TRALPUSH, belongs to the Mediator complex subunit 12 family. MED12L may be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. MED12L is a mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. MED12L is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: mediator complex subunit 12-like; Mediator complex subunit 12-like protein; Mediator of RNA polymerase II transcription subunit 12-like protein; mediator of RNA polymerase II transcription, subunit 12 homolog-like; no opposite paired repeat protein; Thyroid hormone receptor-associated-like protein; Trinucleotide repeat-containing gene 11 protein-like
基因别名: KIAA1635; MED12L; NOPAR; PRO0314; TNRC11L; TRALP; TRALPUSH
UniProt ID: (Human) Q86YW9
Entrez Gene ID: (Human) 116931