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Product Details
MEDEA-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 150-250 on Drosophila melanogaster Medea protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Medea is a gene from the fruit fly Drosophila melanogaster that was one of the first two Smad genes discovered. For both genes, the maternal effect lethality was the basis for selection of their names. Both Medea and Mothers against dpp were identified in a genetic screen for maternal effect mutations that caused lethality of heterozygous decapentaplegic progeny.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG1775; CG1775-PA; CG1775-PB; CG1775-PC; class II Smad; LD22279p; lethal(3)SG36; lethal(3)SG70; Med; Med-PA; Med-PB; Med-PC; Medea; media; Mothers against decapentaplegic homolog
Gene Aliases: anon-EST:Posey121; CG1775; Dmel\CG1775; Dmel_CG1775; dSmad4; E(zen)3; l(3)11m-254; l(3)12m-137; l(3)SG36; l(3)SG70; l(3)XIIm137; MED; medea; SMAD4
Entrez Gene ID: (Fruit fly) 43725
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
transcription factor binding
ubiquitin protein ligase binding
I-SMAD binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
compound eye morphogenesis
transforming growth factor beta receptor signaling pathway
imaginal disc-derived wing morphogenesis
imaginal disc-derived leg morphogenesis
heart development
anatomical structure morphogenesis
dorsal/ventral axis specification
dorsal/ventral pattern formation
cell differentiation
BMP signaling pathway
ovarian follicle cell development
germ-line stem cell population maintenance
retinal ganglion cell axon guidance
activin receptor signaling pathway
somatic stem cell population maintenance
germ-line stem cell division
negative regulation of salivary gland boundary specification
positive regulation of synaptic growth at neuromuscular junction
positive regulation of transcription from RNA polymerase II promoter
neuron development
SMAD protein signal transduction
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