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产品信息
PA5-79629
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK1 (1418-1432aa PEVLRGQQYGRSCDV).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746744
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; mitogen activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
基因别名: MAP3K1; MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
UniProt ID: (Human) Q13233, (Rat) Q62925
Entrez Gene ID: (Human) 4214, (Mouse) 26401, (Rat) 116667
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
zinc ion binding
protein kinase binding
nucleotide binding
JUN kinase kinase kinase activity
ubiquitin-protein transferase activity
JUN kinase binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase binding
sphingolipid binding
metal ion binding
mitogen-activated protein kinase binding
JUN kinase kinase activity
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
MyD88-dependent toll-like receptor signaling pathway
protein phosphorylation
apoptotic process
Fc-epsilon receptor signaling pathway
cellular response to mechanical stimulus
epithelial cell morphogenesis
transforming growth factor beta receptor signaling pathway
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
regulation of mitotic cell cycle
apoptotic mitochondrial changes
phosphorylation
protein ubiquitination
regulation of cell migration
positive regulation of actin filament polymerization
wound healing
regulation of apoptotic process
camera-type eye development
eyelid development in camera-type eye
protein polyubiquitination
response to osmotic stress
peptidyl-serine phosphorylation
negative regulation of actin filament bundle assembly
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
positive regulation of viral transcription
protein oligomerization
