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产品信息
H00004223-M08
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
5E1
抗原
MEOX2 (AAH17021, 1 a.a. approximately 303 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF ASQHHRGHHH HHHHHHHHHQ QQQHQALQTN WHLPQMSSPP SAARHSLCLQ PDSGGPPELG SSPPVLCSNS SSLGSSTPTG AACAPGDYGR QALSPAEAEK RSGGKRKSDS SDSQEGNYKS EVNSKPRKER TAFTKEQIRE LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK WKRVKGGQQG AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSIANED SHDSDHSSEH AHL
靶标信息
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Growth arrest-specific homeobox; Homeobox protein MOX-2; mesenchyme homeo box 2 (growth arrest-specific homeo box); Mesenchyme homeobox 2
基因别名: AI528662; GAX; MEOX2; Mox-2; MOX2
UniProt ID: (Human) P50222, (Rat) P39020, (Mouse) P32443
Entrez Gene ID: (Human) 4223, (Rat) 29279, (Mouse) 17286
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
DNA binding
homeodomain transcription factor
angiogenesis
somite specification
transcription from RNA polymerase II promoter
multicellular organism development
skeletal muscle tissue development
blood circulation
positive regulation of transcription from RNA polymerase II promoter
palate development
limb development
neuron death
negative regulation of cell migration involved in sprouting angiogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
