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产品信息
PA5-41599
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human METTL3 (aa 1-50).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2607005
产品详细信息
Peptide sequence: MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS
Sequence homology: Cow: 100%; Dog: 100%; Goat: 85%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
靶标信息
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit
基因别名: IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44
Entrez Gene ID: (Human) 56339
mRNA splicing, via spliceosome
RNA methylation
adenosine to inosine editing
mRNA processing
circadian rhythm
gene expression
stem cell population maintenance
primary miRNA processing
mRNA destabilization
mRNA methylation
positive regulation of cap-independent translational initiation
primary miRNA methylation
