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METTL3 Antibody (MA5-35248) in ICC/IF
Confocal imaging (Immunocytochemistry) of METTL3 in HeLa cells. Samples were incubated with METTL3 Monoclonal antibody (Product # MA5-35248) using a dilution of 1:100 (Red). The cells were counterstained with alpha Tubulin Mouse mAb (dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 100x.
产品信息
MA5-35248
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC0487
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 2-250 of human METTL3 (Q86U44)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849151
产品详细信息
Immunogen sequence: SDTWSSIQAH KKQLDSLRER LQRRRKQDSG HLDLRNPEAA LSPTFRSDSP VPTAPTSGGP KPSTASAVPE LATDPELEKK LLHHLSDLAL TLPTDAVSIC LAISTPDAPA TQDGVESLLQ KFAAQELIEV KRGLLQDDAH PTLVTYADHS KLSAMMGAVA EKKGPGEVAG TVTGQKRRAE QDSTTVAAFA SSLVSGLNSS ASEPAKEPAK KSRKHAASDV DLEIESLLNQ QSTKEQQSKK VSQEILELL
靶标信息
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; m6a methyltransferase; methyltransferase-like 3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit; N6-adenosine-methyltransferase subunit METTL3
基因别名: 2310024F18Rik; IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44, (Mouse) Q8C3P7
Entrez Gene ID: (Human) 56339, (Mouse) 56335
mRNA binding
RNA methyltransferase activity
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
protein heterodimerization activity
S-adenosyl-L-methionine binding
mRNA (N6-adenosine)-methyltransferase activity
RNA binding
protein binding
methyltransferase activity
transferase activity
RNA metabolism protein
RNA methyltransferase
nucleic acid metabolism protein
mRNA splicing, via spliceosome
RNA methylation
adenosine to inosine editing
mRNA processing
circadian rhythm
gene expression
stem cell population maintenance
primary miRNA processing
mRNA destabilization
mRNA methylation
positive regulation of cap-independent translational initiation
primary miRNA methylation
nucleobase-containing compound metabolic process
mRNA modification
methylation
rhythmic process
