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MFN2 Antibody (702768) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), K562 (Lane 2), U-937 (Lane 3). Hep G2 (Lane 4), IMR-32 (Lane 5), HeLa (Lane 6) and tissue extracts of Mouse heart (Lane 7) and Mouse kidney (Lane 8).The blots were probed with Anti-MFN2 Recombinant Rabbit Monoclonal Antibody (Product # 702768, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4,000 dilution). A ~82 kDa band co... View More
产品信息
702768
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7H42L13
抗原
Peptides corresponding to human Mitofusin 2 [1) aa391-aa410 2) aa742-aa757]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2734817
产品详细信息
This antibody is predicted to react with Monkey, Dog, Cat, Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CPRP 1; HSG protein; hyperplasia suppressor; hypertension related protein 1; Hypertension-related protein 1; MFN 2; Mitochondrial assembly regulatory factor; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2
基因别名: CMT2A; CMT2A2; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; KIAA0214; MARF; MFN2
UniProt ID: (Human) O95140, (Mouse) Q80U63
Entrez Gene ID: (Human) 9927, (Mouse) 170731
blastocyst formation
protein targeting to mitochondrion
autophagy
apoptotic process
response to unfolded protein
mitochondrial membrane organization
multicellular organism development
mitochondrial fusion
protein localization to pre-autophagosomal structure
negative regulation of Ras protein signal transduction
camera-type eye morphogenesis
negative regulation of smooth muscle cell proliferation
mitochondrion localization
cell cycle arrest
blood coagulation
macroautophagy
parkin-mediated mitophagy in response to mitochondrial depolarization
