Invitrogen

MFSD2A Polyclonal Antibody

MFSD2A Antibody in Immunocytochemistry (ICC/IF)

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MFSD2A Antibody (PA5-21049) in ICC/IF

Immunofluorescence of MFSD2A in Rat Lung cells with MFSD2A Polyclonal Antibody (Product # PA5-21049) at 20 µg/mL.

MFSD2A Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-21049

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化 (IHC)

5 µg/mL

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免疫组化（冰冻） (IHC (F))

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免疫细胞化学 (ICC/IF)

20 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

An 18 amino acid peptide near the carboxy terminus of human MFSD2A.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_11152332

产品详细信息

A suggested positive control is rat lung tissue lysate.

PA5-21049 can be used with blocking peptide PEP-1163.

靶标信息

Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.

Fluids and barriers of the CNS

Zhang Y,Wang L,Pan Q,Yang X,Cao Y,Yan J,Wang Y,Tao Y,Fan R,Sun X,Li L

PA5-21049 was used in Western Blot, Immunohistochemistry (Frozen) to investigate the effect of CYM-5442 on vesicle transcytosis, we downregulated and upregulated Mfsd2a expression using a specific AAV prior to evaluation of the TBI model.

Mon Jul 11 00:00:00 UTC 2022

Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.

Fluids and barriers of the CNS

Zhang Y,Wang L,Pan Q,Yang X,Cao Y,Yan J,Wang Y,Tao Y,Fan R,Sun X,Li L

Mon Jul 11 00:00:00 UTC 2022

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.

Nature communications

Zhao L,Li Z,Vong JSL,Chen X,Lai HM,Yan LYC,Huang J,Sy SKH,Tian X,Huang Y,Chan HYE,So HC,Ng WL,Tang Y,Lin WJ,Mok VCT,Ko H

PA5-21049 was used in Western Blotting to reveal transcriptomic alterations underlying brain endothelial cells (EC) ageing that are complex yet pharmacologically reversible.

Fri Sep 04 00:00:00 UTC 2020

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.

Nature communications

Zhao L,Li Z,Vong JSL,Chen X,Lai HM,Yan LYC,Huang J,Sy SKH,Tian X,Huang Y,Chan HYE,So HC,Ng WL,Tang Y,Lin WJ,Mok VCT,Ko H

PA5-21049 was used in Western Blotting to reveal transcriptomic alterations underlying brain endothelial cells (EC) ageing that are complex yet pharmacologically reversible.

Fri Sep 04 00:00:00 UTC 2020

MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis.

Annals of diagnostic pathology

Awad H,Bratasz A,Nuovo G,Burry R,Meng X,Kelani H,Brown M,Ramadan ME,Williams J,Bouhliqah L,Popovich PG,Guan Z,Mcallister C,Corcoran SE,Kaspar B,Michele Basso D,Otero JJ,Kirsch C,Davis IC,Croce CM,Michaille JJ,Tili E

PA5-21049 was used in Immunohistochemistry to study the histopathology of thoraco-abdominal aortic aneurysm and determine the role of miR-155 ablation in the reduction of spinal cord damage.

Mon Oct 01 00:00:00 UTC 2018

Mfsd2a and Glut1 Brain Nutrient Transporters Expression Increase with 32-Week Low and High Lard Compared with Fish-Oil Dietary Treatment in C57Bl/6 Mice.

Current developments in nutrition

Sandoval KE,Wooten JS,Harris MP,Schaller ML,Umbaugh DS,Witt KA

Published figure using MFSD2A polyclonal antibody (Product # PA5-21049) in Western Blot

Mon Oct 01 00:00:00 UTC 2018

生物信息学

蛋白别名: HsMFSD2A; major facilitator superfamily domain containing 2; Major facilitator superfamily domain-containing protein 2A; Mfsd2a; NLS1; sodium-dependent LPC symporter 1; Sodium-dependent lysophosphatidylcholine symporter 1; zgc:101615

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基因别名: 1700018O18Rik; HMFN0656; MCPH15; MFSD2; MFSD2A; NLS1; PP9177; RGD1310174; UNQ300/PRO341

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UniProt ID: (Human) Q8NA29, (Mouse) Q9DA75

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Entrez Gene ID: (Human) 84879, (Rat) 298504, (Mouse) 76574

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功能

phospholipid transporter activity symporter activity

参与通路

fatty acid transport phospholipid transport transcytosis transmembrane transport establishment of blood-brain barrier lipid transport across blood brain barrier transport lipid transport