Invitrogen

MINK1 Polyclonal Antibody

MINK1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 4

MINK1 Antibody (PA5-28901) in ICC/IF

MINK1 Polyclonal Antibody detects MAP4K6 protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in ice-cold MeOH for 5 min. Green: MAP4K6 protein stained by MINK1 Polyclonal Antibody (Product # PA5-28901) diluted at 1:500. Blue: Hoechst 33342 staining.

MINK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

产品信息

PA5-28901

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 901 and 1120 of Human MAP4K6

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2546377

产品详细信息

Recommended positive controls: HepG2.

Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (80%), Xenopus laevis (85%), Bovine (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

MINK1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex.

Science advances

Ban Y,Yu T,Feng B,Lorenz C,Wang X,Baker C,Zou Y

Published figure using MINK1 polyclonal antibody (Product # PA5-28901) in Western Blot

Fri Oct 08 00:00:00 UTC 2021

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.

Molecular cancer research : MCR

Popow O,Paulo JA,Tatham MH,Volk MS,Rojas-Fernandez A,Loyer N,Newton IP,Januschke J,Haigis KM,Näthke I

PA5-28901 was used in Immunocytochemistry-immunoflourescence to identify interaction partners and β-catenin-independent targets of endogenous, full-length APC.

Sun Sep 01 00:00:00 UTC 2019

The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.

eLife

Fearnley GW,Young KA,Edgar JR,Antrobus R,Hay IM,Liang WC,Martinez-Martin N,Lin W,Deane JE,Sharpe HJ

PA5-28901 was used in Western Blotting to show that identifying PTPRK substrates provides insight into its downstream signaling and a potential molecular explanation for its proposed tumor suppressor function.

Fri Mar 29 00:00:00 UTC 2019

生物信息学

蛋白别名: FLJ18426; FLJ38123; FLJ94103; GCK family kinase MINK; hMINK; hMINKbeta; ISK; JLNS; JLNS2; LQT2/5; LQT5; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; MGC33114; Mink 1; Mink 2; Misshapen-like kinase 1; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6

查看更多收起

基因别名: B55; MAP4K6; MINK; MINK1; YSK2; ZC3

查看更多收起

UniProt ID: (Human) Q8N4C8

查看更多收起

Entrez Gene ID: (Human) 50488

查看更多收起

功能

protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding non-receptor serine/threonine protein kinase

参与通路