Invitrogen

MKL1 Polyclonal Antibody

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MKL1 Antibody (PA5-68893) in WB

Western blot analysis of MKL1 on mouse NIH-3T3 cells. The sample was probed with a MKL1 polyclonal antibody (Product # PA5-68893) using a primary antibody dilution of 1.25 µg/mL.

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产品信息

PA5-68893

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide corresponding to a region of mouse MKL1 (aa 721-770).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein A

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2691009

产品详细信息

This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 86%; Human: 79%; Mouse: 100%; Pig: 86%; Rabbit: 86%; Rat: 100%; Zebrafish: 75%

靶标信息

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: basic SAP and coiled-coil domains; Basic SAP coiled-coil transcription activator; megakaryoblastic leukemia (translocation) 1 homolog; Megakaryoblastic leukemia 1 protein homolog; Megakaryocytic acute leukemia protein homolog; mixed lineage leukemia; MKL/myocardin-like protein 1; MRTF-A; Myocardin-related transcription factor A

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基因别名: AMKL; Bsac; Mal; Mkl1; Mrtf-A; Mrtfa

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UniProt ID: (Mouse) Q8K4J6

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Entrez Gene ID: (Mouse) 223701

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功能

transcription regulatory region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity actin binding actin monomer binding protein binding leucine zipper domain binding DNA-binding transcription factor

参与通路

transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter positive regulation of transcription via serum response element binding negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation negative regulation of apoptotic signaling pathway