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产品信息
PA5-37105
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to residues in human MRTF-B
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553910
产品详细信息
This antibody detects endogenous protein at a molecular weight of 118 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTA-276F8.1; gene trap insertion site 4-1; Megakaryoblastic leukemia 2; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MRTF-B; Myocardin-related transcription factor B
基因别名: ENSMUSG00000075401; Gt4-1; KIAA1243; mKIAA1243; MKL2; MRTF-B; MRTFB; NPD001; RGD1560833
UniProt ID: (Human) Q9ULH7, (Mouse) P59759
Entrez Gene ID: (Human) 57496, (Mouse) 239719, (Rat) 100362470
transcription, DNA-templated
muscle organ development
positive regulation of striated muscle tissue development
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
cell-cell adhesion
in utero embryonic development
liver development
heart morphogenesis
regulation of transcription, DNA-templated
multicellular organism development
heart development
gene expression
regulation of gene expression
cell differentiation
positive regulation of transcription, DNA-templated
blood vessel morphogenesis
embryonic organ development
cardiac muscle tissue development
