Invitrogen

MLH3 Polyclonal Antibody

MLH3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MLH3 Antibody (PA5-106564) in IHC (P)

Immunohistochemistry analysis of MLH3 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MLH3 polyclonal antibody (Product # PA5-106564) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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产品信息

PA5-106564

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human MLH3(Accession Q9UHC1), corresponding to amino acid residues E526-S576.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2854232

产品详细信息

Antibody detects endogenous levels of total MLH3.

靶标信息

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。