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产品信息
PA5-33917
产品规格
种属反应
Hamster,
Human,
Mouse,
Pig,
Rabbit
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 15 amino acid peptide from internal region of human MAP3K9.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551285
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Hamster, Rabbit, Pig (100%).
靶标信息
MAP3K9 (MLK1) is a serine/threonine protein kinase that functions in the MAP kinase pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity)
基因别名: E130314H24Rik; I79_014266; MAP3K9; MEKK9; MLK1; PRKE1
UniProt ID: (Human) P80192, (Mouse) Q3U1V8
Entrez Gene ID: (Human) 4293, (Pig) 100155753, (Rabbit) 100341731, (Chinese hamster) 100762934, (Mouse) 338372
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase activity
protein binding
ATP binding
protein homodimerization activity
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
