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产品信息
PA5-148378
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived Human MAP3K10/MLK2 fragment
偶联物
形式
Liquid
浓度
100 µg/mL
纯化类型
Antigen affinity chromatography, Protein A
保存液
PBS, pH 7
内含物
0.03% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
MAP3K10 (MLK2) is a serine/threonine kinase which has been shown to activate MAPK8/JNK and MKK4/SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
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生物信息学
蛋白别名: MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MLK1; PRKE1; Protein kinase MST
基因别名: MAP3K10; MEKK10; MLK2; MST
UniProt ID: (Human) Q02779
Entrez Gene ID: (Human) 4294
apoptotic process
signal transduction
smoothened signaling pathway
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
protein autophosphorylation
