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MLL4 Antibody (PA5-116906) in WB
Western blot analysis of MLL4 in various lysates. Samples were incubated with MLL4 Polyclonal antibody (Product # PA5-116906) using a dilution of 1:800, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.
产品信息
PA5-116906
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1370-1570 of human KMT2B (NP_0555421)
偶联物
形式
Liquid
浓度
0.81 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901536
产品详细信息
Positive Samples: THP-1, Mouse testis, Mouse brain
Immunogen sequence: GLSDEDYEIL SGLPDSVLYT CGPCAGAAQP RWREALSGAL QGGLRQVLQG LLSSKVVGPL LLCTQCGPDG KQLHPGPCGL QAVSQRFEDG HYKSVHSFME DMVGILMRHS EEGETPDRRA GGQMKGLLLK LLESAFGWFD AHDPKYWRRS TRLPNGVLPN AVLPPSLDHV YAQWRQQEPE TPESGQPPGD PSAAFQGKDP A
靶标信息
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Histone-lysine N-methyltransferase 2B; histone-lysine N-methyltransferase 2B-like; histone-lysine N-methyltransferase MLL4; KMT2D; lysine (K)-specific methyltransferase 2B; Lysine N-methyltransferase 2B; mixed lineage leukemia 2; mixed lineage leukemia gene homolog 2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog; Trithorax homolog 2; trithorax homologue 2; WBP-7; WW domain binding protein 7; WW domain-binding protein 7
基因别名: 2610014H22Rik; CXXC10; HRX2; KIAA0304; KMT2B; mKIAA0304; MLL1B; MLL2; MLL4; TRX2; WBP-7; WBP7
UniProt ID: (Human) Q9UMN6, (Mouse) O08550
Entrez Gene ID: (Human) 9757, (Mouse) 75410, (Rat) 102550344
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
methyltransferase activity
transferase activity
metal ion binding
molecular_function
histone modifying enzyme
ovarian follicle development
transcription, DNA-templated
memory
oocyte differentiation
gene silencing
ovulation
chromatin-mediated maintenance of transcription
histone H3-K4 methylation
regulation of histone H3-K4 methylation
histone H3-K4 trimethylation
regulation of transcription, DNA-templated
chromatin modification
methylation
histone lysine methylation
