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产品信息
PA5-120529
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MMP12 (NP_002417.2).
偶联物
形式
Liquid
浓度
0.73 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914101
产品详细信息
Positive test controls include: A-549. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space.
Immunogen sequence: DEFWTTHSGG TNLFLTAVHE IGHSLGLGHS SDPKAVMFPT YKYVDINTFR LSADDIRGIQ SLYGDPKENQ RLPNPDNSEP ALCDPNLSFD AVTTVGNKIF F
靶标信息
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22. 3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3.4.24.65; Macrophage elastase; Macrophage metalloelastase; macrophage-metalloelastase; matrix metallo protease; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12; matrix metalloproteinase 12 (macrophage elastase); Matrix metalloproteinase-12; ME; MGC138506; MME; MMP; MMP-12; MMPs
基因别名: AV378681; HME; ME; MME; Mmel; MMP-12; MMP12
UniProt ID: (Human) P39900, (Mouse) P34960, (Rat) Q63341
Entrez Gene ID: (Human) 4321, (Mouse) 17381, (Rat) 117033
proteolysis
response to organic cyclic compound
extracellular matrix disassembly
collagen catabolic process
wound healing, spreading of epidermal cells
response to drug
positive regulation of epithelial cell proliferation involved in wound healing
wound healing
positive regulation of epithelial cell proliferation
