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产品信息
PA5-116704
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 104-272 of human MMP13 (NP_0024181)
偶联物
形式
Liquid
浓度
1.16 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901335
产品详细信息
Positive Samples: 293T, HeLa, MCF7, A-549
Immunogen sequence: YNVFPRTLKW SKMNLTYRIV NYTPDMTHSE VEKAFKKAFK VWSDVTPLNF TRLHDGIADI MISFGIKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFLVAAHE FGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ SLYGPGDED
靶标信息
MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Collagenase; Collagenase 3; collagenase-1; Collagenase-3; Collagenase3; interstitial collagenase; matrix metallo protease; matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; MMP; MMP-13; MMPs; Procollagenase 3; UMRCASE
基因别名: Clg; CLG3; MANDP1; MMP-13; Mmp1; MMP13
UniProt ID: (Human) P45452, (Mouse) P33435
Entrez Gene ID: (Human) 4322, (Mouse) 17386, (Rat) 171052
fibronectin binding
metalloendopeptidase activity
serine-type endopeptidase activity
calcium ion binding
collagen binding
zinc ion binding
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
peptidase activity
metallopeptidase activity
hydrolase activity
metal ion binding
metalloprotease
luteolysis
osteoblast differentiation
response to hypoxia
endochondral ossification
growth plate cartilage development
proteolysis
heart development
parturition
response to mechanical stimulus
extracellular matrix disassembly
bone mineralization
collagen catabolic process
embryonic hindlimb morphogenesis
response to drug
peptide catabolic process
response to estrogen
cellular protein metabolic process
estrous cycle
bone morphogenesis
cellular response to fluid shear stress
positive regulation of pancreatic trypsinogen secretion
receptor internalization
cartilage development
ossification
