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产品信息
PA1-22527
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli expressed active rat 72-kDa type IV collagenase (catalytic domain).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2146118
产品详细信息
PA1-22527 detects MMP-2 in Rat samples.
靶标信息
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
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生物信息学
蛋白别名: 72 kDa gelatinase; 72 kDa type IV collagenase; CLG 4A; Collagenase; Gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metalloproteinase 2; Matrix metalloproteinase-2; MMP; MMP-2; MMPs; PEX; Progelatinase A; TBE1
基因别名: Mmp2
UniProt ID: (Rat) P33436
Entrez Gene ID: (Rat) 81686
angiogenesis
ovarian follicle development
ovulation from ovarian follicle
luteinization
response to hypoxia
blood vessel maturation
intramembranous ossification
proteolysis
response to oxidative stress
negative regulation of cell adhesion
female pregnancy
embryo implantation
parturition
aging
response to radiation
response to mechanical stimulus
peripheral nervous system axon regeneration
response to activity
cell migration
positive regulation of cell migration
collagen catabolic process
response to retinoic acid
response to cytokine
response to nicotine
endodermal cell differentiation
response to drug
response to hydrogen peroxide
positive regulation of apoptotic process
response to estrogen
positive regulation of innate immune response
negative regulation of vasoconstriction
skeletal system morphogenesis
tissue remodeling
response to electrical stimulus
response to hyperoxia
face morphogenesis
bone trabecula formation
prostate gland epithelium morphogenesis
cellular response to amino acid stimulus
cellular response to cytokine stimulus
cellular response to interleukin-1
cellular response to estradiol stimulus
cellular response to fluid shear stress
