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产品信息
H00064210-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MMS19 (AAH07298, 1 a.a. approximately 293 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRELLELSCC HSCPFSSTAA AKCFAGLLNK HPAGQQLDEF LQLAVDKVEA GLGSGPCRSQ AFTLLLWVTK ALVLRYHPLS SCLTARLMGL LSDPELGPAA ADGFSLLMSD CTDVLTRAGH AEVRIMFRQR FFTDNVPALV QGFHAAPPDV KPNYLKGLSH VLNRLPKPVL LPELPTLLSL LLEALSCPDC VVQLSTLSCL QPLLLEAPQV MSLHVDTLVT KFLNLSSSPS MAVRIAALQC MHALTRLPTP VLLPYKPQVI RALAKSLDDK KRLVRKEAVS ARGEWFLLGS PGS
靶标信息
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hMMS19; homolog of yeast MMS19; MET18 homolog; MMS19 cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair protein homolog; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
基因别名: hMMS19; MET18; MMS19; MMS19L
UniProt ID: (Human) Q96T76
Entrez Gene ID: (Human) 64210
